Structural and magnetic properties of manganite-based multilayers, La_2/3Sr_1/3MnO₃/CaMnO₃, composed of ferromagnetic metals and antiferromagnetic insulator barriers are investigated in this work. Compounds of similar lattice parameters were used to build the samples, so we expect an excellent stacking of the different layers along the structure. To get a first insight of this system, the crystalline structure of a series of samples, grown on (1 0 0) SrTiO₃ and (1 0 0) MgO single-crystalline substrates, has been studied. X-ray diffraction patterns show that the structure is strongly textured in the (1 0 0) direction when grown on SrTiO₃, regardless the composition of the bottom layer. A different result is found on the same system grown on MgO: when the buffer layer is CaMnO₃, the structure grows in the (1 1 0) orientation while it grows in the (1 0 0) direction when the bottom layer is La_2/3Sr_1/3MnO₃. Magnetic coupling of the ferromagnetic layers across the antiferromagnetic spacer has been studied with magnetization measurements.