artículo con referato
"Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action"
Jorge R.A. Diaz, Gerardo Enrique Camí, Malva Liu-González, Daniel R. Vega, Daniela Vullo, Américo Juárez, José C. Pedregos and Claudiu T. Supuran
J. Enzyme Inhib. Med. Chem. 31(6) (2016) 1102-1110
Abstract
Three salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole (Hats) were prepared and characterized by physico-chemical methods. The p-toluensulfonate, the methylsulfonate, and the chlorhydrate monohydrate salts of Hats were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) and as anticonvulsants and diuretics, since many CAIs are clinically used as pharmacological agents. The three Hats salts exhibited diuretic and anticonvulsant activities with little neurotoxicity. The human (h) isoforms hCA I, II, IV, VII, IX, and XII were inhibited in their micromolar range by these salts, whereas pathogenic beta and gamma CAs showed similar, weak inhibitory profiles.
DEPARTAMENTO FISICA DE LA MATERIA CONDENSADA
