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artículo con referato
"Venlafaxine besylate monohydrate"
C.H. Corvalan and D.R. Vega
Acta Cryst. E 69(12) (2013) o1737-o1738
Abstract
The title compound {systematic name: [2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]dimethylazanium benzene­sulfonate monohydrate}, C17H28NO2+·C6H5O3S-·H2O, is a besylate salt hydrate of the anti­depressant drug venlafaxine. In the crystal, besylate anions and water mol­ecules self-assemble, forming hydrogen-bonded dimers linked around inversion centers, with graph set R44(6). The crystal packing features a chain of alternate dimers and venlafaxine cations in the b-axis direction with the components linked by O–HO hydrogen bonds and C–HO and C–Hπ inter­actions. This is the first example of a venlafaxine cation with a closed conformation, as it features an intra­molecular N–HO inter­action involving the protonated N atom.
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