artículo con referato
"Venlafaxine besylate monohydrate"
C.H. Corvalan and D.R. Vega
Acta Cryst. E 69(12) (2013) o1737-o1738
Abstract
The title compound {systematic name: [2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]dimethylazanium benzenesulfonate monohydrate}, C17H28NO2+·C6H5O3S-·H2O, is a besylate salt hydrate of the antidepressant drug venlafaxine. In the crystal, besylate anions and water molecules self-assemble, forming hydrogen-bonded dimers linked around inversion centers, with graph set R44(6). The crystal packing features a chain of alternate dimers and venlafaxine cations in the b-axis direction with the components linked by O–H⋯O hydrogen bonds and C–H⋯O and C–H⋯π interactions. This is the first example of a venlafaxine cation with a closed conformation, as it features an intramolecular N–H⋯O interaction involving the protonated N atom.
DEPARTAMENTO FISICA DE LA MATERIA CONDENSADA