Two crystal structures of sulfonamide salts were studied by X-Ray diffraction. The compound C₂H₅N₄O₂S₂⁺·H₂O·Cl^- (I), (Hats·H₂O·Cl, Hats = protonated 5-amino-2-sulfonamide-1,3,4-thiadiazole) crystallizes in orthorhombic space group, P2₁2₁2₁, with unit cell parameters a = 10.047(4), b = 5.186(2), c = 16.766(6) Å and the compound C₂H₅N₄O₂S₂⁺·CH₃O₃S^- (II), crystallizes in monoclinic space group, Cc, with unit cell parameters a = 5.378(3), b = 19.707(6), c = 10.014(5) Å, beta = 99.97(1)°. The molecules in compound I are arranged in a helix of alternating water and Hats molecules. Helixes are interconnected by hydrogen bonds provided by Cl^- ions and one ring with a graph set R₆⁴ (12) is determined. The crystal structure of compound II presents mesylate and Hats molecules bonded by two hydrogen bond determining a ring with a graph set R₂²(8).