The prediction of the response of a closed system to external perturbations is one of the central problems in quantum mechanics, and in this respect, the local density of states (LDOS) provides an in-depth description of such a response. The LDOS is the distribution of the overlaps squared connecting the set of eigenfunctions with the perturbed one. Here, we show that in the case of closed systems with classically chaotic dynamics, the LDOS is a Breit-Wigner distribution under very general perturbations of arbitrary high intensity. Consequently, we derive a semiclassical expression for the width of the LDOS which is shown to be very accurate for paradigmatic systems of quantum chaos. This Letter demonstrates the universal response of quantum systems with classically chaotic dynamics.