artículo con referato
"The calcium-binding properties of pamidronate, a bone-resorption inhibitor"
D. Fernández, D. Vega and A. Goeta
Acta Cryst. C 58(19) (2002) m494-m497
Abstract
The title compound, calcium bis(3-ammonio-1-hydroxypropylidene-1,1-bisphosphonate) dihydrate, Ca2+·2C3H10NO7P2-·2H2O, consists of calcium octahedra arranged in columns along the c axis and coordinated by hydrogen-bonded molecular anions. The Ca2+ cation lies on a twofold axis. Pamidronate adopts a twisted conformation of the hydroxyalkylamine backbone that enables the formation of an intramolecular N–H⋯O hydrogen bond. The molecular anion is chelating monodentate as well as bidentate, with an O⋯O bite distance of 3.0647 (15) Å.
DIVISION MATERIA CONDENSADA