The crystal structure of racemic Venlafaxine hydrochloride, C₁₇H₂₈NO₂⁺·Cl^-, consists of two types of parallel chains formed by translated Venlafaxine⁺ cations, hydrogen bonded by Cl^- anions, and characterized by the opposite chirality of their constituent molecules. These chains organize in two different types of broad layers of opposite handedness, related by a glide plane.